ArtPoster
TitelPeriventricular Leukomalacia - A neonatal disease pattern with far reaching consequences
TopicNeonatologie
Einleitung

Background: Periventricular leukomalacia (PVL) may develop pre-, peri-, and postnatally. PVL has far-reaching consequences for the premature infant and its family. The prevalence of PVL in premature infants weighing less than 1500 grams at birth has been reported with 3 – 5 % [1]. The hallmark of PVL is a disruption of cerebral perfusion leading to cerebral hypoxia. The resultant loss of neurons, astrocytes, and other glia cells leads to the development of cerebral cysts. Both diffuse and focal cystic lesions have been described. Neurodevelopmental impairment and epilepsy are common sequelae.

Patient/en und Methoden

Aim of this study: At the Elisabeth Children´s Hospital Oldenburg, a retrospective analysis of all known cases of PVL diagnosed during the period of 01/2016 thru 12/2020 was conducted. Cases were categorized according to the most likely time of insult (pre-, peri-, and postnatally).

Methods: Cases of PVL were extracted by means of a database search for the specific international classification of diseases (ICD) code. Pregnancies and postnatal events were reconstructed and cases were categorized as either pre-, peri-, or postnatal complications. Risk factors for each category had been predefined.

Ergebnisse

Results: Eight patients met search criteria. Three cases each were assigned to the groups of prenatal and perinatal complications. Two cases were categorized as postnatal complications. Motor and neurocognitive development, as well as cerebral ultrasound findings were documented.

Schlussfolgerung/Diskussion

Conclusions: When compared to international standards, the prevalence of PVL in premature infants of less than 1500 grams at birth was below average. The cases included represent a heterogeneous group of patients showing a balanced number of pre-, peri-, and postnatal complications. Therefore, structural deficits at the University Hospital of Oldenburg are unlikely. All patients exhibit symptoms of neurodevelopmental impairment emphasizing the importance of high quality diagnostics and clinical management before and after birth to prevent the occurrence of PVL.

review
Autor*in 1Buhre Johanna Carl von Ossietzky Universität Oldenburg/Elisabeth Kinderkrankenhaus Oldenburg/Abteilung für Neonatologie , Pädiatrische Intensivmedizin und Kinderkardiologie
Autor*in 2Lange Matthias Carl von Ossietzky Universität Oldenburg/Elisabeth Kinderkrankenhaus Oldenburg/Abteilung für Neonatologie , Pädiatrische Intensivmedizin und Kinderkardiologie
Autor*in 3Sandra Grebe Carl von Ossietzky University Oldenburg/Klinikum Oldenburg/Department of Gynecology and Obstetrics
Autor*in 4Axel Heep Carl von Ossietzky Universität Oldenburg/Elisabeth Kinderkrankenhaus Oldenburg/Abteilung für Neonatologie , Pädiatrische Intensivmedizin und Kinderkardiologie
Autor*in 5Beske Florian Carl von Ossietzky Universität Oldenburg/Elisabeth Kinderkrankenhaus Oldenburg/Abteilung für Neonatologie , Pädiatrische Intensivmedizin und Kinderkardiologie